氧感应通路与肿瘤细胞对放疗和化疗的耐药作用相关。随着肿瘤的生长，肿瘤细胞可以感应到环境中氧气的紧张并重新编程与癌细胞生存和治疗抵抗密切相关的关键途径。这种重新编程的其中一个例子是通过上调缺氧诱导因子α（HIF-alpha）和激活HIF信号下游通路。

张博士的实验室主要致力于研究氧感应通路，以及它们如何促进肿瘤的发展以及治疗耐药。张博士的实验室正在实施新的基因组和蛋白质组学方法，以确定乳腺癌和肾癌中氧感应信号的重要新治疗靶点。在本次云讲堂直播间，张博士将为我们带来围绕氧感应通路而发现的治疗新靶点，包括乳腺癌新靶点BBOX1以及肾癌新靶点ZHX2、SFMBT1、TBK1等。

09月10日晚19:00--20:00，张青教授将为我们带来《乳腺癌和肾癌治疗新靶点的发现和确证》，欢迎大家准时收看！

Hypoxia is associated with resistance towards radiation and chemotherapy. As tumors grow, they can sense the oxygen tension and reprogram critical pathways that are important for cancer cell survival and therapy resistance. One of examples is through upregulation of hypoxia inducible factor alpha (HIF-α) and activation of HIF signaling downstream pathways. Dr. Zhang’s lab is mainlyinterested in studying the oxygen-sensing pathway and how they contribute tothe development of tumors as well as therapeutic resistance. Dr. Zhang’s lab is implementing novel genomic and proteomic approaches to identify important new therapeutic targets in oxygen sensing signaling in breast and kidney cancers. During this talk, Dr. Zhang will present on identifying BBOX1 as a new therapeutic target in breast cancer. In addition, Dr. Zhang will present on identifying a few new therapeutic targets in kidney cancer, including ZHX2,SFMBT1 and TBK1.